Each capsule contains:
Atenolol 50mg ,Hydrchlorothiazide 25mg ,Amiloride 2.5mg
Atenolol is a selective B.blocker which binds to beta-adrenergic receptors in the heart, & other tissuesInterfering with binding of adrenaline & nor adrenaline to beta adrenergic receptors so , it Inhibits sympathetic stimulation , finally it decreases cardiac output and rennin release and decreases blood pressure.
Hydrochlorothiazide(HCZ) is a diuretic which propagates kidney filtration of sodium and fluids decreasing blood volume ,cardiac output and blood pressure.
Amiloride is K .sparing diuretic which prevent the excessive K loss avoiding hypokalemia caused by HCZ.
Studies show thatthe combination ofhydrochlorothiazide and amiloride in theRatio of 10 : 1 is optimal to achieve theseeffects
Atenretic is indicated in moderate to sever degrees of hypertension avoiding hypokalemia caused by HCZ.
Dosages and administration:
1 capsule once daily
Package of 3 strips(each has 10 capsules).