Ionops

Composition:

Active :

Ganciclovir 0.15 gm/10 gm

Preservative :

Benzalkonium chloride 0.02%

Properties:

Ganciclovir ophthalmic drops 0.15% contains the active ingredient, ganciclovir, which is a guanosine derivative that, upon phosphorylation, inhibits DNA replication by herpes simplex viruses (HSV). Ganciclovir is transformed by viral and cellular thymidine kinases (TK) to ganciclovir triphosphate, which works as an antiviral agent by inhibiting the synthesis of viral DNA in 2 ways: competitive inhibition of viral DNA-polymerase and direct incorporation into viral primer strand DNA, resulting in DNA chain termination and prevention

Indications:

• Indicated for the treatment of acute herpetic keratitis (dendritic ulcers).

Dosages and administration:

• The recommended dosing regimen for Ionops is 1 drop in the affected eye 5 times per day (approximately every 3 hours while awake) until the corneal ulcer heals, and then 1 drop 3 times per day for 7 days.

Presentation:

Bottle of  10gm sterile viscous drops.