Alendomax plus

Composition

  • Alendronic acid 70 mg
  • Vitamin D3 2800 I.U.

 

Mechanism of action

  Alendronic acid 70mg

  • Inhibition of Osteoclast genesis.
  • Shortening of OC survival.
  • Inhibiting the vitality of ruffled borders.

 

  Vitamin D3 2800 IU

  • Is an essential nutrient needed by the body to help absorb calcium from food.
  • It is also essential for healthy bones

 

    Dosage:     

             One tablet Once weekly      

                  

Indication

  • Treatment of postmenopausal osteoporosis 

 

  • in patients at risk of vitamin D insufficiency.

 

  • Reduces the risk of vertebral and hip fractures.

 

  • Treatment and reduction of risk of glucocorticoid induced osteoporosis in postmenopausal women not receiving estrogen.

 

 Contraindications

 

  • Hypersensitivity to the active ingredients.

 

  • Abnormalities of the esophagus and other factors which delay esophageal empting such as stricture.

 

  • Inability to stand or sit upright for at least 30 minutes.

 

 

 

Drug-Drug interactions

 

  • Calcium supplements, and antacids will interfere with Alendronate.
  • Therefore, patients must wait at least 30 minutes after taking Alendronate before taking any other medical product.

 

  • Olestra(used in the preparation of traditionally high-fat foods), mineral oils, orlistat, and bile acid like cholestyramine may impair the absorption of vitamin D3.

 

 

Special populations

 

Pregnancy and lactation:

  • No studies on pregnancy and lactation and should not been given to them.

 

Elderly population:

  • No age related difference in the efficacy or safety profiles of Alendronate, so no dose adjustment for them.

 

Renal impairment:

 

  • It is not recommended for patients with renal impairment where glomerular filtration rate is less than 35 ml/min, due to lack of experience.

N.B.   GFR is a test used to detect that kidney working correctly, normal value 90-110ml/min,

  • If < 60 means renal disease,
  • If < 35 means renal impairment,
  • If < 15 means kidney have stopped working .

 

  • No dose adjustment is necessary for patients with GFR greater than 35 ml/min.

 

 

  • Dose and Administration
  • One tablet once weekly.

 

  • If miss a dose , patient should take one tablet on the morning after they remember.

 

  • Must be taken with water only (not mineral water or juice) at least 30 minutes before the first food.

 

  • Should only be swallowed after getting up for the day with a full glass of water (not less than 200 ml)

 

  • Patients should not lie down for at least 30 minutes after taking Alendomax plus

 

 

Package and price

 

  • Alendomax Plus Box :   1 strip

 

  • 2 tablets.